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KMID : 0603820100160030179
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 3 p.179 ~ p.185
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Effects of Benzene, Phenol and Hydroquinone on Proliferation, Differentiation and Migration of Human Eosinophilic EoL-1 Cells
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Moon So-Hee
Yang Eun-Ju
Song Bo-Bae
Kim Bo-Mi
Lee Ji-Sook
Kim In-Sik
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Abstract
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Benzene is known as a ubiquitous air pollutant and has a carcinogenic influence on the human body. Benzene is also metabolized to other volatile organic compounds (VOCs) in the body such as phenol and hydroquinone (HQ). The metabolites are accumulated and further oxidized by myeloperoxidase in bone marrow. They act as toxic agents and cause a variety of diseases, including cancer, atopic dermatitis and asthma. In this study, we examined the effects of benzene and its metabolites on proliferation, differentiation and chemotaxis of EoL-1 cells, the human eosinophilic leukemia cell line. These chemicals had no effect on the proliferation of EoL-1 cells. Benzene decreased the differentiation of EoL-1 cells induced by butyric acid. HQ was induced the cell death during butyric acid-induced EoL-1 cell differentiation. In a chemotaxis experiment, benzene, phenol and HQ enhanced the cell migration induced by Lkn-1 but not by MCP-1, eotaxin, MIP-1α and RANTES. These findings provide the effect of VOCs on the regulation of eosinophil-involved immune response.
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KEYWORD
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Benzene, Phenol, Hydroquinone, Eosinophils, Immune response
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